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March 28, 2001

Cocaine and Pregnancy—Time to Look at the Evidence

Author Affiliations

Author Affiliation: Columbia School of Public Health, New York, NY.

JAMA. 2001;285(12):1626-1628. doi:10.1001/jama.285.12.1626

In this issue of THE JOURNAL, Frank and colleagues1 present a systematic review of studies assessing possible relationships between maternal cocaine use during pregnancy and several childhood outcomes. The authors are thoughtful and rigorous in their approach and carefully evaluate the physiological plausibility of the outcomes under question and the methodological strengths and constraints of the studies reviewed. They considered 36 studies worthy of review; these reported on 17 prospectively recruited cohorts with examiners blinded to cocaine exposure status.