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Contempo Updates
June 27, 2001

Physiological Neuroimaging: Emerging Clinical Applications

Author Affiliations

Author Affiliation: Cerebrovascular Section, NeuroImaging Laboratory and Interventional Neuroradiology Service, Neuroradiology Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo.


Contempo Updates Section Editor: Alice T. D. Hughes, MD, Fishbein Fellow.

JAMA. 2001;285(24):3065-3068. doi:10.1001/jama.285.24.3065

Physiological imaging tools have provided a window for the study of central nervous system physiology and pathophysiology in living humans, particularly in the areas of cerebral ischemia and cognitive neuroscience. The first studies in living humans were performed nearly 50 years ago and involved measurements of whole brain blood flow using radiotracers.1 It is now possible to measure many dynamic physiological processes within small regions of the brain. These processes include blood flow, oxygen and glucose metabolism, electrical activity, nuclear magnetic spectra, and neurotransmitter receptor sites.