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Piccirillo JF, Mager DE, Frisse ME, Brophy RH, Goggin A. Impact of First-Line vs Second-Line Antibiotics for the Treatment of Acute Uncomplicated Sinusitis. JAMA. 2001;286(15):1849–1856. doi:https://doi.org/10.1001/jama.286.15.1849
Author Affiliations: Division of Clinical Outcomes Research, Department of Otolaryngology-Head and Neck Surgery (Dr Piccirillo), Washington University School of Medicine, St Louis, Mo (Dr Brophy); Express Scripts Inc, Maryland Heights, Mo (Drs Frisse and Goggin and Mr Mager).
Context Studies suggest little benefit in relief of acute sinusitis symptoms
from the use of newer and more expensive (second-line) antibiotics instead
of older and less expensive (first-line) antibiotics. However, researchers
have failed to include development of complications and cost of care in their
Objective To compare the effectiveness and cost of first-line with second-line
antibiotics for the treatment of acute uncomplicated sinusitis in adults.
Design, Setting, and Patients Retrospective cohort study using a pharmaceutical database containing
demographic, clinical (International Classification of Diseases,
Ninth Revision), treatment, and charge information for 29 102
adults with a diagnosis of acute sinusitis receiving initial antibiotic treatment
between July 1, 1996, and June 30, 1997.
Main Outcome Measures Absence of additional claim for an antibiotic in the 28 days after the
initial antibiotic, presence of a claim for a second antibiotic, serious complications
of sinusitis, and direct charges and use for the acute sinusitis treatment.
Results There were 17 different antibiotics prescribed in this study. The majority
(59.5%) of patients received 1 of the first-line antibiotics. The overall
success rate was 90.4% (95% confidence interval [CI], 90.0%-90.8%). The success
rate for the 17 329 patients who received a first-line antibiotic was
90.1% and for the 11 773 patients who received a second-line antibiotic
was 90.8%, a difference of 0.7% (95% CI, 0.01%-1.40%; P<.05). There were 2 cases of periorbital cellulitis, one in each
treatment group. The average total direct charge for patients receiving a
first-line antibiotic was $68.98 and a second-line antibiotic was $135.17,
a difference of $66.19 (95% CI, $64.95-$67.43; P<.001).
This difference was due entirely to the difference in charge of antibiotics
and not other charges, such as professional fees, laboratory tests, or emergency
Conclusions Patients treated with a first-line antibiotic for acute uncomplicated
sinusitis did not have clinically significant differences in outcomes vs those
treated with a second-line antibiotic. However, cost of care was significantly
higher for patients treated with a second-line antibiotic.
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