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Featured Clinical Reviews

Contempo Updates
October 24/31, 2001

Drug-Induced Hyperglycemia

Author Affiliations

Author Affiliations: Department of Internal Medicine, Campbell University School of Pharmacy, Buies Creek, NC, and Durham Regional Hospital, Duke University Health System, Durham, NC (Dr Luna); Department of Internal Medicine, Division of Endocrinology, Metabolism and Nutrition, Duke University Medical Center, Durham, NC (Dr Feinglos).


Contempo Updates Section Editors: Alice T. D. Hughes, MD, and Janet M. Torpy, MD, Fishbein Fellows.

JAMA. 2001;286(16):1945-1948. doi:10.1001/jama.286.16.1945

It is well recognized that certain classes of drugs can cause clinically significant elevations in glucose concentrations. Historically, the agents implicated have included β-blockers, thiazide diuretics, corticosteroids, niacin, pentamidine, and others.1,2 Of recent interest are the increasing numbers of reported cases of new-onset diabetes mellitus (DM) in patients receiving treatment with protease inhibitors (PIs) or atypical antipsychotic agents. In most cases the mechanisms by which hyperglycemia occurs are not fully understood, although several possible theories have been proposed for each drug class.1,2

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