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November 7, 2001

The Challenge of Painful Crisis in Sickle Cell Disease

Author Affiliations

Author Affiliation: Division of Hematology, Albert Einstein College of Medicine/Montefiore Hospital, Bronx, NY.

JAMA. 2001;286(17):2152-2153. doi:10.1001/jama.286.17.2152

Acute painful crisis in sickle cell disease is a frequent complication and considerably diminishes the quality of life of patients with this disease.1 The pain of sickle cell crisis is one of the most intense in medicine—it has been compared with that of a severe toothache—and affects the extremities, abdomen, lower back, or multiple sites simultaneously. The unpredictability of such painful episodes adds to their discomfort.