Acute painful crisis in sickle cell disease is a frequent complication
and considerably diminishes the quality of life of patients with this disease.1 The pain of sickle cell crisis is one of the most
intense in medicine—it has been compared with that of a severe toothache—and
affects the extremities, abdomen, lower back, or multiple sites simultaneously.
The unpredictability of such painful episodes adds to their discomfort.
Nagel RL. The Challenge of Painful Crisis in Sickle Cell Disease. JAMA. 2001;286(17):2152–2153. doi:10.1001/jama.286.17.2152
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