[Skip to Navigation]
Sign In
November 14, 2001

Tau and Parkinson Disease

Author Affiliations

Author Affiliations: Centre for Brain Repair and Department of Neurology, University of Cambridge (Dr Spillantini), and Medical Research Council Laboratory of Molecular Biology (Dr Goedert), Cambridge, England.

JAMA. 2001;286(18):2324-2326. doi:10.1001/jama.286.18.2324

Filamentous deposits made of the microtubule-associated protein tau are a defining characteristic of a number of neurodegenerative diseases, including Alzheimer disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and some frontotemporal dementias, such as Pick disease.1 The identification of coding region and intronic (noncoding) mutations in the tau gene in familial frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) has established that dysfunction of tau protein is sufficient to cause neurodegeneration and dementia.2-4

Add or change institution