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December 19, 2001

Immune-Based, Targeted Therapy for Allergic Diseases

Author Affiliations

Author Affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

JAMA. 2001;286(23):3005-3006. doi:10.1001/jama.286.23.3005

Allergic rhinitis is an inflammatory disorder characterized by upper airway symptoms, including nasal congestion, rhinorrhea, sneezing, and itching of the palate, and, in some patients, by conjunctivitis, otitis media with effusion, sinusitis, or asthma.1 The prevalence of allergic rhinitis, a common disease that affects approximately 9% to 22% of the US population,2,3 has increased substantially in the past 20 years.4 Symptoms of seasonal allergic rhinitis recur at times of the year corresponding to the appearance of airborne allergens such as pollens and mold spores. Some patients are symptomatic only during the pollen season while many others are allergic to multiple allergens or have a nonallergic component to their rhinitis so that they are symptomatic through much of the year.