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January 9, 2002

Differential Influence of Maternal Smoking on Infant Birth Weight: Gene-Environment Interaction and Targeted Intervention

Author Affiliations

Author Affiliations: Department of Biobehavioral Health (Drs Vogler and Kozlowski) and Center for Developmental and Health Genetics (Dr Vogler), Pennsylvania State University, University Park.

JAMA. 2002;287(2):241-242. doi:10.1001/jama.287.2.241

Maternal smoking is a significant risk factor for low-birth-weight (LBW) infants, which, in turn, influences infant mortality and the long-term health outcome of surviving infants. Maternal smoking is an ideal target for intervention and the optimal public health outcome would be prevention of all maternal smoking. But given variability in the response to intervention attempts, a secondary strategy is to target more effectively those individuals at highest risk for adverse outcomes.