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February 6, 2002

Postmenopausal Hormone Therapy and Quality of Life: No Cause for Celebration

Author Affiliations

Author Affiliations: Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston Mass.

JAMA. 2002;287(5):641-642. doi:10.1001/jama.287.5.641

Despite the common perception that postmenopausal hormone therapy improves quality of life in women, few randomized clinical trials have addressed this issue. Moreover, the high rates of discontinuation of hormone therapy in the first few years of use in both observational studies1,2 and randomized trials3 cast doubt on this assumption. The study by Hlatky et al4 in this issue of THE JOURNAL presents important and intriguing data regarding hormone therapy and quality of life that were previously lacking. This report is particularly informative because the investigators stratify their results according to the presence or absence of vasomotor flushing symptoms at baseline.