Author Affiliation: Department of Biostatistics, University of Washington, Seattle.
Nonoxynol-9 has been used as a spermicide for more than half a century.
The need for a female-controlled method for preventing acquisition of sexually
transmitted infections (STIs) led to research into nonoxynol-9 as a vaginal
microbicide. By the end of the 1980s, several studies of the in vitro antimicrobial
activity of nonoxynol-9 showed that it had the ability to inactivate various
sexually transmitted pathogens, including Neisseria gonorrhoeae, Chlamydia trachomatis, and human immunodeficiency
virus type 1 (HIV-1).1-3
Animal studies conducted later seemed to confirm the results observed, suggesting
that nonoxynol-9 had high potential as an effective vaginal microbicide for
prevention of STIs.4-6
Richardson BA. Nonoxynol-9 as a Vaginal Microbicide for Prevention of Sexually Transmitted
Infections: It's Time to Move On. JAMA. 2002;287(9):1171–1172. doi:10.1001/jama.287.9.1171
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