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March 13, 2002

From Clinical Trials to Clinical Practice: Bridging the GAP

Author Affiliations

Author Affiliation: Cardiovascular Division, Washington University School of Medicine, St Louis, Mo.

JAMA. 2002;287(10):1321-1323. doi:10.1001/jama.287.10.1321

Evidence-based medicine. The concept seems so simple. Take the best available information from clinical trials and observational studies and apply the results in clinical practice. What in medicine could be more rational or straightforward? Yet despite a rich evidence base for management of cardiovascular disorders,1 study after study has demonstrated disconcertingly low rates of compliance with widely disseminated evidence-based treatment guidelines for managing common cardiovascular conditions including coronary heart disease, heart failure, and hypertension.2-4