Author Affiliations: Department of Pediatrics, Boston University School of Medicine, Boston, Mass (Drs Zuckerman and Frank); and Department of Child Psychiatry, Yale University School of Medicine, New Haven, Conn (Dr Mayes).
In this issue of THE JOURNAL, Singer and colleagues1
report the findings from their prospective cohort study assessing the relationship
between prenatal cocaine exposure and cognitive and developmental outcomes
in 218 cocaine-exposed infants and 197 unexposed infants. After controlling
for prenatal exposure to other drugs, gestational age and size at birth, and
a number of caregiver characteristics, the authors found that infants who
had in utero cocaine exposure scored on average 6 points lower than the comparison
group on the Mental Scale of the Bayley Scales of Infant Development2 at 24 months of age. Rates of clinically important
developmental delay on the scale were doubled in the cocaine-exposed group
compared with the unexposed group (13.7% vs 7.1%, respectively).
Zuckerman B, Frank DA, Mayes L. Cocaine-Exposed Infants and Developmental Outcomes: "Crack Kids" Revisited. JAMA. 2002;287(15):1990–1991. doi:10.1001/jama.287.15.1990
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