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Medical News & Perspectives
April 17, 2002

Hormone Replacement Therapy Falls Out of Favor With Expert Committee

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JAMA. 2002;287(15):1923-1924. doi:10.1001/jama.287.15.1923

Bethesda, Md—Falling in line with the evidence-based medicine trend, an international team of women's health experts is discouraging the use of hormone replacement therapy (HRT) for many postmenopausal conditions. Coronary heart disease, fractures, depression, urinary incontinence—all cited in the past as prime reasons to initiate HRT—are losing favor as valid indications for it, as evidence from high-quality clinical trials accumulates.

In 1992, three major organizations threw their collective weight behind guidelines that pushed physicians to prescribe HRT for women with or at risk of heart disease and osteoporosis. Endorsed by the American College of Physicians, the American College of Family Medicine, and the US Preventive Services Task Force, the guidelines relied almost exclusively on soft data from observational studies and clinical experience.

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