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Medical News & Perspectives
May 15, 2002

Causes Sought for Neural Tube Defects in Infants of Diabetic Pregnant Women

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JAMA. 2002;287(19):2487-2488. doi:10.1001/jama.287.19.2487

Boston—Studies in mice are bringing researchers a step closer to understanding the molecular miscues that can give rise to neural tube defects in infants of women with diabetes. A new character in this medical scenario is the oncogene p53. Notorious for its role in cancer, p53 takes the stage again, this time cast as a villain that helps undermine embryonic development, according to a new report in Genes and Development (2002;16:676-680).