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July 17, 2002

Estrogen Replacement Therapy and Risk of Ovarian Cancer

JAMA. 2002;288(3):368-369. doi:10.1001/jama.288.3.368

By the middle of the 20th century, it was well recognized that elderly women frequently developed severe osteoporosis, resulting in a life complicated by constant back pain and repeated fractures. By the 1970s and 1980s, it became clear that use of estrogenic substances at or near the time of menopause could prevent or treat osteoporosis, and these drugs became widely prescribed and taken. Even before the bone-sparing effects of estrogen were known, these agents were used extensively for the treatment of menopausal symptoms, primarily vasomotor instability and vaginal atrophy.1

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