Author Affiliations: Department of Psychiatry, Washington University School of Medicine, St Louis, Mo (Dr Carney); and Departments of Medicine/Cardiology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn (Dr Jaffe).
Depression is a risk factor for mortality after acute myocardial infarction
(MI), and it predicts a slow recovery and a poor quality of life.1-4 Nevertheless,
only a minority of patients who are depressed after an MI receive treatment
for their depression. In the past, the only available antidepressants had
cardiotoxic effects and were contraindicated for many patients with heart
disease, particularly older patients at risk for orthostatic hypotension and
patients with left bundle branch block.5 Some
of the older antidepressants also have proarrhythmic effects.6
Carney RM, Jaffe AS. Treatment of Depression Following Acute Myocardial Infarction. JAMA. 2002;288(6):750–751. doi:10.1001/jama.288.6.750
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