In Reply: In response to Drs Grodstein and Manson, HRT use is associated with higher SES,1,2 and lower SES is an important risk factor for CHD and overall mortality.3,4 Because of these relationships, we believe that it is appropriate to consider SES as a potentially important confounder of the relationship between HRT and CHD. When reviewing the relationship of HRT to other outcomes for this review, we also considered the effect of SES, as well as many other potential confounders.1
Humphrey LL, Nelson HD, Chan BKS, Nygren P, Allan J, Teutsch S. Relationship Between Hormone Replacement Therapy, Socioeconomic Status, and Coronary Heart Disease. JAMA. 2003;289(1):45. doi:10.1001/jama.289.1.44-b
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