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January 1, 2003

Relationship Between Hormone Replacement Therapy, Socioeconomic Status, and Coronary Heart Disease

Author Affiliations
  • 1Evidence-based Practice Center, Oregon Health & Science University, Portland
  • 2School of Nursing, University of Maryland, Baltimore
  • 3Outcomes Research and Management, Merck and Co Inc, West Point, Pa
JAMA. 2003;289(1):45. doi:10.1001/jama.289.1.44-b

In Reply: In response to Drs Grodstein and Manson, HRT use is associated with higher SES,1,2 and lower SES is an important risk factor for CHD and overall mortality.3,4 Because of these relationships, we believe that it is appropriate to consider SES as a potentially important confounder of the relationship between HRT and CHD. When reviewing the relationship of HRT to other outcomes for this review, we also considered the effect of SES, as well as many other potential confounders.1