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Since the mid-1990s, approximately 150 cases of acute encephalopathy
have been reported in Japanese children with influenza virus infection.1 These cases have been characterized by fever and
rapid onset of encephalopathy and resulted in a high frequency of neurologic
sequelae and death. Most of the children have had laboratory-confirmed evidence
To determine if a similar pattern of influenza-associated encephalopathy
cases is occurring in the United States, CDC is requesting information on
any case meeting certain criteria. The criteria include a person aged <18
years with altered mental status or personality change lasting >24 hours and
occurring within 5 days of the onset of an acute febrile respiratory illness,
laboratory or rapid diagnostic test evidence of acute influenza virus infection
associated with the respiratory illness, and diagnosis of the condition in
the United States.
Cases that have occurred after December 31, 1997, can be reported to
Tim Uyeki (telephone 404-639-0277 or e-mail email@example.com)
or Jim Sejvar (telephone 404-639-4657 or e-mail firstname.lastname@example.org)
at CDC. The information will be used to determine if additional investigation
Request for Information About Acute Encephalopathy Cases in Children With Influenza. JAMA. 2003;289(6):696. doi:10.1001/jama.289.6.696
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