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February 26, 2003

Vitamins and Hormone Therapy for Coronary AtherosclerosisVitamins and Hormone Therapy for Coronary Atherosclerosis

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(8):982. doi:10.1001/jama.289.8.982-a

In Reply: In response to Dr Hathcock, the predefined primary outcome of our trial was coronary angiographic change, with worse ranks assigned to women who died or had an intercurrent MI. We agree that there is no 1-to-1 relationship between clinical outcome and angiographic change, which is why women who died or had an MI were not imputed an equivalent angiographic score, but rather were assigned a rank that was lower than the rank of the worst angiographic score. The nonparametric test we used thus relies on the relative ordering of the outcomes, not their numeric value, and we do feel it is reasonable to rank deaths and MIs lowest.