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February 26, 2003

Idiopathic vs Hereditary PancreatitisIdiopathic vs Hereditary Pancreatitis

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(8):983-985. doi:10.1001/jama.289.8.983a

To the Editor: Dr Simon and colleagues report that the hereditary pancreatitis–associated cationic trypsinogen (PRSS1) gene mutation, R122H, was present in 5 (10%) of 50 patients with idiopathic pancreatitis.1 We have a number of concerns about this report.

First, they did not reference 3 closely related studies.2-4 In particular, 1 study evaluated the known hereditary pancreatitis–associated PRSS1 gene mutations in a large cohort of patients with idiopathic pancreatitis.3