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April 16, 2003

Clopidogrel and Percutaneous Coronary Interventions

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(15):1925-1927. doi:10.1001/jama.289.15.1925-a

To the Editor: Dr Steinhubl and colleagues1 found that following PCI with clopidogrel therapy, in addition to traditional aspirin therapy, significantly reduced the likelihood of adverse events at 1 year. They also found that a loading dose of clopidogrel at least 3 hours prior to the procedure did not reduce events at 28 days, but that a loading dose of clopidogrel at least 6 hours prior to PCI may offer some benefit.