Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: We have 2 concerns about the
methodology of the trial reported by Dr Steinhubl and colleagues.1
First, the authors used symptoms of angina pectoris as objective evidence
of ischemia. In reality, symptoms of angina pectoris are subjective and may
not correlate well with the presence of cardiac ischemia. Previous studies
have used more objective criteria such as electrocardiographic changes or
elevated biochemical markers of cardiac ischemia.2
Borja J, Pérez I, De la Cruz G. Clopidogrel and Percutaneous Coronary Interventions. JAMA. 2003;289(15):1925–1927. doi:10.1001/jama.289.15.1925-a
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