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April 16, 2003

Clopidogrel and Percutaneous Coronary Interventions

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(15):1925-1927. doi:10.1001/jama.289.15.1925-a

To the Editor: We have 2 concerns about the methodology of the trial reported by Dr Steinhubl and colleagues.1

First, the authors used symptoms of angina pectoris as objective evidence of ischemia. In reality, symptoms of angina pectoris are subjective and may not correlate well with the presence of cardiac ischemia. Previous studies have used more objective criteria such as electrocardiographic changes or elevated biochemical markers of cardiac ischemia.2