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April 16, 2003

Clopidogrel and Percutaneous Coronary Interventions

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(15):1925-1927. doi:10.1001/jama.289.15.1925-a

To the Editor: Despite of the absence of benefit associated with clopidogrel pretreatment at 28 days, Dr Steinhubl and colleagues1 drew attention to a trend in favor of benefit among those who received clopidogrel loading 6 to 24 hours prior to PCI. Patients who received clopidogrel pretreatment within 6 hours prior to PCI did not experience any benefit. While it is biologically plausible that a longer pretreatment interval might be necessary, this observation would be rendered more credible if a relationship could be demonstrated between pretreatment interval and magnitude of benefit. Although such a supplementary analysis might be underpowered, the results may be informative nonetheless.