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April 16, 2003

Reducing the Risk of Stroke

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(15):1927-1929. doi:10.1001/jama.289.15.1927

To the Editor: In their summary statements of the evidence, Dr Straus and colleagues1 sometimes failed to clarify the findings of single, groundbreaking randomized clinical trials, which may be more important than meta-analyses of multiple smaller studies. An example is their passing mention of the European Secondary Prevention Study 2 (ESPS-2), the largest study of aspirin and dipyridamole in secondary stroke prevention.2