To the Editor: In vitro studies and experiments
in animal models have found that cannabinoids modulate immune cell function.1 However, investigations of immune effects in human
subjects are scarce and contradictory. Gene expression of cannabinoid receptors
in peripheral blood mononuclear cells may be altered among marijuana users.2 Experimental data in healthy persons have found
abnormalities in T lymphocyte and natural killer (NK) cell function, but have
not confirmed that these alterations might affect susceptibility to infections.3 We sought to investigate cell-mediated immune response
and cytokine release in cannabis users.
Pacifici R, Zuccaro P, Pichini S, Roset PN, Poudevida S, Farré M, Segura J, de la Torre R. Modulation of the Immune System in Cannabis Users. JAMA. 2003;289(15):1929–1931. doi:10.1001/jama.289.15.1929-a