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JAMA 100 Years Ago
May 7, 2003


Author Affiliations

JAMA 100 Years Ago Section Editor: Jennifer Reiling, Assistant Editor.

JAMA. 2003;289(17):2292. doi:10.1001/jama.289.17.2292-a

During recent years workers in bacteriology have been largely occupied with the study of the soluble products of bacteria and with their action on the animal body. In view of the brilliant results which followed the discovery and investigation of the soluble toxins of the tetanus and diphtheria bacilli, it was natural to seek similar poisons in connection with the other pathogenic bacteria with the hope of also obtaining specific anti-toxic agents to combat them. However, it soon became apparent that many bacteria did not exert their injurious effects through the agency of soluble toxins, and efforts to obtain curative sera by injections of fluid cultures have met with complete failure in the case of most pathogenic bacteria.