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May 14, 2003

Cholinesterase Inhibitors for Alzheimer DiseaseCholinesterase Inhibitors for Alzheimer Disease

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(18):2359. doi:10.1001/jama.289.18.2359-a

To the Editor: Dr Trinh and colleagues1 concluded that ChIs have a "modest" beneficial role in treating neuropsychiatric symptoms. Their results do not support these claims.

The trials included in the meta-analysis did not include patients with significant behavioral symptomatology. They were designed to enroll mildly to moderately impaired patients who could complete cognitive testing and who had no significant behavioral problems. Furthermore, some allowed use of various psychotropic medications, thereby potentially confounding the results.