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May 28, 2003

Hormone Therapy and the Brain: Déjà Vu All Over Again?

Author Affiliations

Author Affiliations: Departments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, and the San Francisco Veterans Affairs Medical Center, San Francisco.

JAMA. 2003;289(20):2717-2719. doi:10.1001/jama.289.20.2717

More than 33% of women and 20% of men aged 65 and older will develop dementia during their lifetime.1 With the aging of the US population, the number of individuals with Alzheimer disease (AD) and other forms of dementia is expected to quadruple over the next 50 years.2 This projected exponential increase in the prevalence of dementia, along with the anticipated impact on families and society, highlights the imperative for developing preventive strategies. There is also increasing interest in preventing mild cognitive impairment (MCI), a cognitive and functional state in between normal aging and dementia, that frequently progresses to dementia.3