Author Affiliations: Departments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, and the San Francisco Veterans Affairs Medical Center, San Francisco.
More than 33% of women and 20% of men aged 65 and older will develop
dementia during their lifetime.1 With the aging
of the US population, the number of individuals with Alzheimer disease (AD)
and other forms of dementia is expected to quadruple over the next 50 years.2 This projected exponential increase in the prevalence
of dementia, along with the anticipated impact on families and society, highlights
the imperative for developing preventive strategies. There is also increasing
interest in preventing mild cognitive impairment (MCI), a cognitive and functional
state in between normal aging and dementia, that frequently progresses to
Yaffe K. Hormone Therapy and the Brain: Déjà Vu All Over Again? JAMA. 2003;289(20):2717–2719. doi:10.1001/jama.289.20.2717
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