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May 28, 2003

Optimal Digoxin Concentrations for Patients With Heart FailureOptimal Digoxin Concentrations for Patients With Heart Failure

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(20):2643. doi:10.1001/jama.289.20.2643-a

To the Editor: We have 2 concerns about the study of Mr Rathore and colleagues.1 First, about 70% of ingested digoxin is eliminated renally.2 Nonetheless, the small differences in glomerular filtration rate and in dosing between the 3 digoxin groups reported by Rathore et al, although statistically significant, certainly do not explain the more than 2-fold increase in SDCs between groups.