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Grand Rounds
Clinician's Corner
June 11, 2003

Nonalcoholic Fatty Liver Disease: An Underrecognized Cause of Cryptogenic Cirrhosis

Author Affiliations

Author Affiliations: Departments of Medicine (Drs Clark and Diehl) and Epidemiology (Dr Clark), Johns Hopkins University, Baltimore, Md.


Grand Rounds at The Johns Hopkins Bayview Medical Center Section Editors: David B. Hellmann, MD, Charles Weiner, MD, Stephen D. Sisson, MD, The Johns Hopkins Hospital, Baltimore, Md; David S. Cooper, MD, Contributing Editor, JAMA.

JAMA. 2003;289(22):3000-3004. doi:10.1001/jama.289.22.3000

Cryptogenic cirrhosis is a common cause of liver-related morbidity and mortality in the United States. Nonalcoholic fatty liver disease (NAFLD) is now recognized as the most common cause of cryptogenic cirrhosis. However, the diagnosis of cirrhosis in patients with NAFLD appears to be delayed compared with those with other chronic liver diseases and thus carries a higher mortality rate. This delay in diagnosis is illustrated in our case of a 53-year-old man who presented with hepatic hydrothorax and ascites, whose workup revealed cirrhosis due to NAFLD. Although a diagnosis of presumed NAFLD can be made noninvasively, a definitive diagnosis requires a liver biopsy specimen. A biopsy specimen is also important for detecting histologically advanced disease, which may be clinically silent and undetected by aminotransferases or diagnostic imaging. Although there are no proven treatments, recommendations for patients with NAFLD include avoidance of hepatotoxins and aggressive management of associated conditions, such as hypertriglyceridemia and type 2 diabetes mellitus.