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July 9, 2003

Epstein-Barr Virus and Risk of Multiple Sclerosis—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(2):193. doi:10.1001/jama.290.2.193-a

In Reply: Good and colleagues1,2 described inhibition of myelopoiesis by lymphocytes from patients with aplastic anemia. Furthermore, an important experimental link between the immune system and hematopoiesis was the observation of fatal aplastic anemia in "runt disease," due to inoculation of parental lymphocytes into a host and subsequent graft vs host disease, reported by Hilgard et al,3 among others. We have used this model to demonstrate the role of type I cytokines4 and "bystander" killing of innocent hematopoietic stem cells.5