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July 23/30, 2003

Breast Cancer After Hodgkin Disease: Hope for a Safer Cure

JAMA. 2003;290(4):529-531. doi:10.1001/jama.290.4.529

For more than a century, Hodgkin disease (HD) has served as a paradigm for developing modern oncology concepts. Yet the success of using radiotherapy, chemotherapy, or both for cure of a formerly lethal disease has not come without a price.1-3 Even though control of HD in early-stage and overall survival is approximately 90% at 10 years,4 survival is decreasing with more years of observation, primarily due to a higher than expected number of deaths from second malignancies. At 20 years after diagnosis, the cumulative risk of developing second cancers is approximately 10%, exceeding the cumulative risk of dying from the primary early-stage disease.4