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July 23/30, 2003

Diet First, Then Medication for Hypercholesterolemia

JAMA. 2003;290(4):531-533. doi:10.1001/jama.290.4.531

Managing diet is the key to treating all common lipid disorders. Previous observations suggest that intensive dietary intervention can decrease serum cholesterol and low-density lipoprotein cholesterol (LDL-C) levels by approximately 30%.1 The findings of Jenkins and colleagues2 reported in this issue of THE JOURNAL indicate that intensive dietary therapy may be just as effective in reducing cholesterol levels as the starting dosage of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) drug.