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August 13, 2003

Long-term Use of Hydroxyurea for Sickle Cell AnemiaLong-term Use of Hydroxyurea for Sickle Cell Anemia

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(6):752. doi:10.1001/jama.290.6.752-a

To the Editor: I have 4 concerns about the study by Dr Steinberg and colleagues.1 First, the authors did not analyze the differences in outcomes between patients with low vs high initial levels of hemoglobin F (HbF) that rose with hydroxyurea treatment. Such an analysis would best assess the authors' hypothesis that the hydroxyurea-induced rise in HbF confers hydroxyurea's beneficial effect on morbidity.