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August 13, 2003

Long-term Use of Hydroxyurea for Sickle Cell AnemiaLong-term Use of Hydroxyurea for Sickle Cell Anemia

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(6):752. doi:10.1001/jama.290.6.752-a

To the Editor: Dr Steinberg and colleagues1 reported a 40% reduction in mortality among patients with SCA who used hydroxyurea (P = .04), without statistically significant toxicity. The authors pointed out that theirs was an observational study of self-selected treatment. Despite the authors' caution, we are concerned that they are overly optimistic in their conclusions.