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August 13, 2003

Cannabinoids and Immune Function

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(6):754. doi:10.1001/jama.290.6.754-a

To the Editor: In their Research Letter, Dr Pacifici and colleagues1 found that long-term users of cannabis had lower natural killer cell counts, lymphocyte proliferation, and levels of interleukin 2 (IL-2), as well as increased levels of IL-10 and transforming growth factor-β-1. The authors concluded that this pattern of results may reflect immunosuppressive properties of cannabis.