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August 27, 2003

Medications That Prolong the QT Interval—Reply

JAMA. 2003;290(8):1025. doi:10.1001/jama.290.8.1025-a

To the Editor: In their article about the QT interval, Dr Al-Khatib and colleagues1 described the propensity of a number of drugs for causing QT prolongation. The authors categorized the synthetic opioid methadone as an "improbable" agent regarding its potential to delay repolarization. Their review, however, was based on an expert panel discussion from August 2000. Since that time, a number of new findings have emerged that, taken together, suggest that an association between methadone and QT prolongation can no longer be considered "improbable."