To the Editor: In their article about the QT
interval, Dr Al-Khatib and colleagues1 described
the propensity of a number of drugs for causing QT prolongation. The authors
categorized the synthetic opioid methadone as an "improbable" agent regarding
its potential to delay repolarization. Their review, however, was based on
an expert panel discussion from August 2000. Since that time, a number of
new findings have emerged that, taken together, suggest that an association
between methadone and QT prolongation can no longer be considered "improbable."
Krantz MJ, Martell BA, Arnsten JH, Gourevitch MN. Medications That Prolong the QT Interval—Reply. JAMA. 2003;290(8):1025. doi:10.1001/jama.290.8.1025-a
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