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September 10, 2003

Postdiarrheal Shiga Toxin–Mediated Hemolytic Uremic Syndrome

Author Affiliations

Author Affiliations: Division of Nephrology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City.

JAMA. 2003;290(10):1379-1381. doi:10.1001/jama.290.10.1379

Postdiarrheal Shiga toxin–mediated hemolytic uremic syndrome (HUS) is the major cause of acute renal failure in infants and young children1 and is a substantial cause of mortality and chronic morbidity. Adolescents who develop postdiarrheal HUS fare as well as younger children2 but adults, especially elderly individuals, experience a higher incidence of death and disability.3