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September 17, 2003

Disseminating Health Care Innovation

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(11):1456-1457. doi:10.1001/jama.290.11.1456-a

In Reply: In response to Drs van Leth and Lange, we do not wish to comment on the appropriateness or otherwise of surrogates in clinical trials in HIV, or the confounding of efficacy and tolerability measures discussed by them. However, time to treatment failure was one of the examples we used to describe a situation in which use of a composite outcome is appropriate, when there is a single underlying clinical occurrence (treatment failure) that can occur in multiple ways.