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October 1, 2003

Effects of Estrogen Plus Progestin on Risk of DementiaEffects of Estrogen Plus Progestin on Risk of Dementia

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(13):1706-1708. doi:10.1001/jama.290.13.1706-a

To the Editor: The WHIMS investigators reported that therapy with continuous combined CEE plus MPA increased the risk for probable dementia1 and was associated with impaired cognitive function in some women.2 These findings are consistent with a study suggesting that MPA might mitigate the positive effect of estrogen on cognition.3

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