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October 22/29, 2003

Optimal Intervals and Techniques for Screening Sigmoidoscopy—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(16):2122-2123. doi:10.1001/jama.290.16.2122-a

To the Editor: Dr Schoen and colleagues1 found that among 9317 individuals who had negative results of a screening sigmoidoscopy, 6 (0.06%) were found to have colorectal cancer by repeated sigmoidoscopy 3 years later. An absolute risk reduction of 0.06% means that 1667 individuals would need to undergo repeat 3-year sigmoidoscopy in order to find 1 case of cancer, assuming none of these cancers would have been discovered by other less invasive methods of screening or by incidental findings.