Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: The increased prevalence of
coronary heart disease (CHD) in women with monosomy X (Turner syndrome) has
been attributed to their premature ovarian failure, which causes loss of estrogen
effect and excess adiposity.1,2 However,
the longstanding view of estrogen as a cardioprotective agent responsible
for the relative protection from CHD enjoyed by women compared with men has
recently been challenged.3 To investigate
the possibility that haploinsufficiency for X-chromosome genes, rather than
gonadal insufficiency, contributes to the increased CHD risk in monosomy X,
we compared fasting lipid profile, glucose and insulin levels, and body composition
in young, nonobese women with Turner syndrome and in 46,XX women with premature
Cooley M, Bakalov V, Bondy CA. Lipid Profiles in Women With 45,X vs 46,XX Primary Ovarian Failure. JAMA. 2003;290(16):2127–2128. doi:10.1001/jama.290.16.2127
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