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October 22/29, 2003

Lipid Profiles in Women With 45,X vs 46,XX Primary Ovarian Failure

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(16):2127-2128. doi:10.1001/jama.290.16.2127

To the Editor: The increased prevalence of coronary heart disease (CHD) in women with monosomy X (Turner syndrome) has been attributed to their premature ovarian failure, which causes loss of estrogen effect and excess adiposity.1,2 However, the longstanding view of estrogen as a cardioprotective agent responsible for the relative protection from CHD enjoyed by women compared with men has recently been challenged.3 To investigate the possibility that haploinsufficiency for X-chromosome genes, rather than gonadal insufficiency, contributes to the increased CHD risk in monosomy X, we compared fasting lipid profile, glucose and insulin levels, and body composition in young, nonobese women with Turner syndrome and in 46,XX women with premature ovarian failure.