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November 12, 2003

Depression and Health-Related Quality of Life—ReplyDepression and Health-Related Quality of Life—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(18):2404. doi:10.1001/jama.290.18.2404-a

In Reply: We agree with Dr Gandjour that the association between depressive symptoms and disease-specific health status was expected.1 However, prior studies had not simultaneously compared the contributions of depressive symptoms and cardiac function with disease-specific health status. Our study's novel finding was that while depressive symptoms were strongly associated with cardiac-specific health status, 2 traditional measures of cardiac function (ie, ejection fraction and ischemia) were not. Indeed, depressive symptoms were as strongly associated with cardiac-specific health status as was exercise capacity, one of the primary variables used to validate the Seattle Angina Questionnaire.2