Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: We agree with Dr Gandjour that the
association between depressive symptoms and disease-specific health status
was expected.1 However, prior studies had
not simultaneously compared the contributions of depressive symptoms and cardiac
function with disease-specific health status. Our study's novel finding was
that while depressive symptoms were strongly associated with cardiac-specific
health status, 2 traditional measures of cardiac function (ie, ejection fraction
and ischemia) were not. Indeed, depressive symptoms were as strongly associated
with cardiac-specific health status as was exercise capacity, one of the primary
variables used to validate the Seattle Angina Questionnaire.2
Ruo B, Whooley M. Depression and Health-Related Quality of Life—ReplyDepression and Health-Related Quality of Life—Reply. JAMA. 2003;290(18):2404. doi:10.1001/jama.290.18.2404-a
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