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November 19, 2003

Relationship Between Ambient Ozone and Exhaled Nitric Oxide in Children

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(19):2546-2547. doi:10.1001/jama.290.19.2546-a

To the Editor: Ozone, an oxidant of photochemical smog, is known to cause a variety of respiratory effects, including diminished lung function, exacerbation of respiratory symptoms, and inflammation of airways.1 To date, lung inflammation has been measured only invasively, by analysis of bronchoalveolar lavage fluid obtained from adults exposed to relatively high concentrations of ozone while exercising.2,3 We used exhaled nitric oxide4 to measure the relationship between ambient ozone levels and inflammation of airways.