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Medical News & Perspectives
November 19, 2003

Cancer Researchers Target Angiogenesis

JAMA. 2003;290(19):2529-2533. doi:10.1001/jama.290.19.2529

More than 5 years ago, a New York Times article described stunning effects of angiogenesis inhibitors in eradicating cancerous tumors in mice, unleashing a media frenzy. But the agents have failed to perform as hoped in the clinic. More than 60 antiangiogenic agents are in clinical trials in the United States, and while they appear to be safe and well tolerated, positive therapeutic outcomes have been scarce .