Changes in the expression of imprinted genes—genes differentially
expressed depending on whether they are inherited from the mother or father—have
been linked to a variety of human malignancies. Scientists from the National
Cancer Institute, studying the phenomenon in mice, have identified some of
the dramatic differences between the effects of maternal and paternal genomes
in work that provides insight on how factors other than genetic mutations
can cause cancer (published October 27 in the online edition of the Proceedings of the National Academy of Sciences of the United
States of America; http://www.pnas.org).
Hampton T. Parental Influence on Cancer. JAMA. 2003;290(20):2655. doi:10.1001/jama.290.20.2655-a
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