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December 17, 2003

Acarbose for Patients With Hypertension and Impaired Glucose ToleranceAcarbose for Patients With Hypertension and Impaired Glucose Tolerance

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(23):3066. doi:10.1001/jama.290.23.3066-a

To the Editor: I question whether the legend in Figure 4 of the study by Dr Chiasson and colleagues1 is accurate. A total of 1368 participants were included in the overall analysis. According to the authors' Table 1 , 702 of these participants (51%) had hypertension at baseline. Thus, at the time of study entry, the remaining 666 participants were apparently free of hypertension. Yet 1368 participants are listed as "at risk" on the Kaplan-Meier plot of the effect of acarbose on the probability of remaining free of hypertension. I trust that the log-rank and Cox proportional model statistical tests for treatment effect were actually performed on the 666 participants who were free of hypertension at baseline.