Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: I agree with Dr Brotman that our
cutoff value for a low risk of recurrent VTE is assay-specific. Similar to
the exclusion of acute VTE or pulmonary embolism, an appropriate cutoff must
be defined for each different D-dimer assay. I therefore disagree with Brotman's
suggestion that D-dimer levels less than half the threshold level used for
exclusion of recurrent VTE can be used to identify patients at low risk of
Eichinger S. Identifying Patients at Risk of Recurrent Venous Thromboembolism. JAMA. 2003;290(24):3192. doi:10.1001/jama.290.24.3192-a
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