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December 24/31, 2003

Identifying Patients at Risk of Recurrent Venous Thromboembolism

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(24):3192. doi:10.1001/jama.290.24.3192-a

In Reply: I agree with Dr Brotman that our cutoff value for a low risk of recurrent VTE is assay-specific. Similar to the exclusion of acute VTE or pulmonary embolism, an appropriate cutoff must be defined for each different D-dimer assay. I therefore disagree with Brotman's suggestion that D-dimer levels less than half the threshold level used for exclusion of recurrent VTE can be used to identify patients at low risk of future VTE.