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January 14, 2004

Association Between Thimerosal-Containing Vaccine and Autism

JAMA. 2004;291(2):180. doi:10.1001/jama.291.2.180-b

To the Editor: Dr Hviid and colleagues1 found no increase in relative risk of core autism from thimerosal in vaccines using the Danish autism registry. Denmark removed thimerosal from infant vaccines in mid-1992. The findings of Hviid et al are based on finding fewer older (born 1990-1992) thimerosal-exposed children than younger (born 1992-1996) unexposed children in the 2000 registry year. However, a sizable percentage of autism cases, skewing toward older children, are lost from the registry each year. Thus, the authors' finding is likely to be biased due to incomplete recordkeeping.

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